AMPK (AMP-activated protein kinase) is a pivotal cell enzyme required to orchestrate the burning of fat and sugar. The first study was trying to figure out if curcumin had a mechanism that could specifically help protect against non-alcohol fatty liver disease; a common consequence of obesity-related health problems. This study showed that curcumin turned on AMPK, induced fat burning, while inhibiting fat deposition in liver cells. The researchers concluded that these mechanisms were adequate to conclude that, “curcumin extract may be active in the prevention of fatty liver.”
In a second study, researchers fed a high fat diet to mice to the point of inducing fatty liver. In the mice that were also fed curcumin, it prevented the mice from developing fatty liver. It did this by activating AMPK to orchestrate the gene signaling that enhances fat burning. The researchers concluded that curcumin was of use “as a therapeutic for hepatic steatosis [fatty liver].”
This new Korean research is a continuation of a decade of science relating to curcumin and obesity. I have previously reviewed their work and the work of others in my article, Curcumin Now Touted as a Significant Weight Loss & Disease Prevention Nutrient. Curcumin is an excellent nutrient to add to any person’s weight management plan.